BOF

1-What is the mechanism of action of tacrolimus?

      
   A.A Mercaptopurine antagonist
   B.A Interferes with purine synthesis
   C.A Inhibits inosine monophosphate dehydrogenase 
   D.A Monoclonal antibody against IL-2 receptor 
   E.A Decreases IL-2 release by inhibiting calcineurin

2-Which one of the following is least associated with thymomas?

      
   A.A Syndrome inappropriate ADH 
   B.A Myasthenia gravis
   C.A Red cell aplasia 
   D.A Dermatomyositis 
   E.A Motor neurone disease


3-Which one of the following statements is true regarding autosomal recessive polycystic kidney disease?ia

      
   A.A Onset is typically in the third decade 
   B.A Liver involvement is rare 
   C.A Is due to a defect on chromosome 16 
   D.A More common than autosomal dominant polycystic kidney disease 
   E.A May be diagnosed on prenatal ultrasound







4-Each one of the following features is seen in phenylketonuria, except:

      
   A.A Learning difficulties 
   B.A Seizures
   C.A Eczema 
   D.A Recurrent infections 
   E.A 'Musty' urine

phenylalanine hydroxylase deficiency,AR, Guthrie test 5-9day after birth


5-Each one of the following predisposes to cataract formation, except:

      
   A.A Down's syndrome 
   B.A Hypercalcaemia 
   C.A Diabetes mellitus 
   D.A Long-term steroid use 
   E.A Uveitis

6-Which one of the following causes of delayed puberty is associated with short stature?

      
   A.A Klinefelter's syndrome
   B.A Turner's syndrome
   C.A Polycystic ovarian syndrome 
   D.A Androgen insensitivity 
   E.A Kallman's syndrome

7-Which of the following types of renal stones are said to have a semi-opaque appearance on x-ray?ia

      
   A.A Calcium oxalate 
   B.A Cystine stones 
   C.A Urate stones 
   D.A Xanthine stones 
   E.A Triple phosphate stones

8-What is the most common clinical pattern seen in motor neuron disease?

      
   A.A Progressive muscular atrophyia  (best prognosis)
   B.A Bulbar palsyia  (worst prognosis)
   C.A Spinocerebellar ataxia 
   D.A Relapsing-remitting 
   E.A Amyotrophic lateral sclerosis

9-Which one of the following is least recognised as a cause of clubbing?ia

      
   A.A Grave's disease 
   B.A Empyema
   C.A Cyanotic congenital heart disease 
   D.A Coeliac diseasei
   E.A Cystic fibrosis



10-Which of the following congenital heart defects may progress to Eisenmenger's syndrome

   
   A.A Tetralogy of Fallot 
   B.A Coarctation of the aorta 
   C.A Patent ductus arteriosus
   D.A Tricuspid atresia
   E.A Transposition of the great arteries