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Monday, 7 June 2010

Small intestin

• Iron and Ca absorbed from proximal Small intestine but B12 absorbed from ileum and need intrinsic factor that secreted from funds of stomach



• Coeliac disease: investigation of choice endoscopy and biopsy from prx.Small intestine (never diagnose it without biopsy) >> increase interaepithilium lymphocyte, subtotal villous atrophy and absence of Small intestine folds.



• Coeliac disease Screening by antiendomyseal Ab and anti tissue transglutiminase antibodies also used for follow up and evaluation of ttt. HLA-DQ2 in 90% and can used for rule out the diagnosis of coeliac disease if no response to ttt.



• Coeliac disease Iron and folate deficiency so there is macro and micro RBCs in blood film and MCV can be N/low or high



• Coeliac disease, Spleen atrophy what u will do for? Also DXA should do even in ttt as osteoporosis ass with it and dosent decrease with ttt

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